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Genitourinary cancer expertise

MUSC Hollings Cancer Center is a national leader in treating genitourinary cancers. Genitourinary cancers include:

Genitourinary cancers affect the urinary and male reproductive systems, but they can vary widely in how they develop, how quickly they grow and how they are treated.

At MUSC Hollings Cancer Center, our specialists have extensive experience diagnosing and treating genitourinary cancers, from early-stage cancers that may need close monitoring or minimally invasive treatment to advanced cancers that need a combination of therapies.

Your care team brings together experts in urology, medical oncology, radiation oncology, radiology, pathology, genetics and other specialties. Together, they review your diagnosis and develop a personalized treatment plan based on your specific cancer, its stage and your overall health and treatment goals.

As South Carolina’s only National Cancer Institute-designated cancer center, Hollings also gives patients access to innovative clinical trials and the latest advances in genitourinary cancer care.

U.S. News & World Report Best Regional Hospitals 2026-2027 Cancer

MUSC Hollings Cancer Center Named South Carolina’s Best Hospital for Cancer Care

MUSC Hollings Cancer Center has been nationally recognized by U.S. News & World Report as High Performing for Cancer Care as well as ranked as the No. 1 hospital in South Carolina for Cancer Care 2026–2027, affirming our excellence in preventing, diagnosing, treating, and supporting patients with cancer. As the only National Cancer Institute (NCI)-designated cancer center in South Carolina, Hollings blends cutting-edge research, multidisciplinary clinical expertise and advanced treatments to deliver outcomes that stand out on a national scale.

The Hollings difference

I hope my story can encourage other men to get prostate cancer screenings and possibly save a life. Every life is important.

Larry Ferguson

Genitourinary cancer treatment

At Hollings, our genitourinary cancer specialists understand that every patient and every cancer is different. Your care team will work with you to develop a treatment plan based on your type of cancer, how advanced it is, your overall health and your goals.

Personalized treatment options

Depending on your cancer type and stage, your treatment plan may involve one or more of the following approaches.

  • Active surveillance closely monitors certain slow-growing cancers or small tumors that do not need treatment right away.
  • Surgery removes the cancer and may be performed using minimally invasive or advanced robotic techniques.
  • Radiation therapy uses high-energy radiation to destroy cancer cells while limiting damage to nearby healthy tissue.
  • Tumor ablation destroys cancerous tissue without surgically removing it using extreme cold, focused sound waves, electrical pulses or other methods.
  • Chemotherapy uses powerful medicines to destroy cancer cells or stop them from growing and dividing throughout the body.
  • Immunotherapy uses medicines that help the immune system to better recognize and attack cancer cells.
  • Targeted therapy uses medicines that attack specific features of cancer cells that help them to grow and survive.
  • Clinical trials evaluate promising new treatments and approaches and may give eligible patients access to therapies that are not yet widely available.

Throughout your care, our goal is not only to treat your cancer effectively but also to protect your quality of life and long-term health.

Advanced surgical options

Hollings offers both traditional and minimally invasive surgery for genitourinary cancers. Our surgeons use advanced robotic techniques when appropriate, which may allow them to operate through smaller incisions. For some patients, that means less pain and a faster recovery.

Hollings offers several types of surgery to remove all or part of the prostate or kidney. These include single-port robotic surgery, which is performed through one small incision; multi-port robotic surgery, which uses several small incisions; and traditional open surgery.

Refer a genitourinary cancer patient

To refer a genitourinary cancer patient to Hollings, please call 843-985-3972.

Nurse navigator support

Our genitourinary cancer nurse navigators will help you understand what to expect during treatment and answer questions you may have. Brigitte Kettering, MSN, RN, OCN (ketterin@musc.edu), works with prostate cancer patients. Kristin Powers, BSN, RN (powmeekk@musc.edu), works with patients with bladder, kidney, testicular and other genitourinary cancers.

Make an appointment

Contact us at 843-792-9300 to schedule an appointment with one of our genitourinary cancer specialists.

Genitourinary cancer care providers

Accepting New Patients
Eric Wallen

Eric Wallen, M.D., FACS

4.9/5.0 - 264 rating
Specialties
  • Urology
  • Bladder Cancer
Locations (3)
  • Bluffton, SC
  • Charleston, SC
  • Mount Pleasant, SC
Accepting New Patients
David Marshall

David Marshall, M.D., MS

4.9/5.0 - 168 rating
Specialties
  • Radiation Oncology
  • Gastrointestinal Cancer
Locations (2)
  • Charleston, SC
  • Mount Pleasant, SC
Accepting New Patients
Stephen Savage

Stephen Savage, M.D.

4.8/5.0 - 517 rating
Specialties
  • Urology
  • Bladder Cancer
Locations (2)
  • Charleston, SC
  • Mount Pleasant, SC
Accepting New Patients
Kevin Becker

Kevin Becker, M.D.

4.9/5.0 - 213 rating
Specialties
  • Medical Oncology
  • Bladder Cancer
Locations (2)
  • Charleston, SC
  • Mount Pleasant, SC
Accepting New Patients
Thai Ho

Thai Ho, M.D., Ph.D.

4.8/5.0 - 59 rating
Specialties
  • Medical Oncology
  • Bladder Cancer
Locations (1)
  • Charleston, SC
Accepting New Patients
Harriet Eldredge-Hindy

Harriet Eldredge-Hindy, M.D.

4.9/5.0 - 182 rating
Specialties
  • Radiation Oncology
  • Breast Cancer
Locations (2)
  • Charleston, SC
  • Mount Pleasant, SC

Clinical trials for genitourinary cancer

As a National Cancer Institute-designated cancer center, we firmly believe that clinical trials are an important part of cancer care. Clinical trials show us whether new treatments work better than existing treatments. That’s important for future patients. But clinical trials are also important for current patients, because they offer the possibility of early access to new therapies or protocols that could become the standard-of-care in the future.

We offer a variety of genitourinary cancer clinical trials, including trials developed by researchers at Hollings, industry trials and trials organized by other cancer centers. Some trials focus on new therapies, while others test new ideas for supportive care or screening. Learn more about clinical trials at Hollings and see our current genitourinary cancer clinical trials and trials for specific types of genitourinary cancer:

Hollings is also a member of NRG Oncology and the Alliance for Clinical Trials in Oncology. These cooperative groups organize multi-institution cancer clinical trials that happen across the country. Through membership in these groups, Hollings is able to offer a wider range of clinical trials.

Ask your doctor if there is a clinical trial that fits your needs.

Specialized genitourinary cancer care

Prostate cancer screening

Finding prostate cancer early can make it easier to treat. A prostate-specific antigen (PSA) test is a blood test that measures the level of PSA, a protein made by the prostate. A higher-than-normal PSA level can be a sign of prostate cancer, although other conditions can also cause PSA levels to rise.

When and how often you should be screened depends on factors such as your age, family history and other risk factors. Talk with your doctor about your individual risk and which cancer screenings are right for you.

Hereditary Cancer Clinic

Some inherited genetic changes can increase the risk of prostate, kidney and other genitourinary cancers. Knowing whether cancer runs in your family can help you and your care team better understand your risk and make informed decisions about screening and care.

The Hollings Hereditary Cancer Clinic offers genetic counseling and testing for people who may have an inherited risk of cancer. Our specialists can help you understand your family history, whether genetic testing may be appropriate and what your results could mean for you and your family.

Hollings doctors and researchers are working to improve how prostate, kidney, bladder and other genitourinary cancers are detected and treated. Their research ranges from studying how these cancers develop and respond to treatment to testing new approaches designed to help patients live longer and maintain their quality of life.

Recent research includes:

Hollings researchers also work across specialties to move discoveries from the laboratory into patient care. The Genitourinary Transdisciplinary Cancer Team brings together scientists and clinicians from different areas of expertise to collaborate on research and identify new opportunities to improve genitourinary cancer prevention, diagnosis and treatment.

Genitourinary cancer care locations

MUSC Hollings Cancer Center

Address
86 Jonathan Lucas Street
Charleston, SC 29425
Get Directions
Hours
Specialties
  • Biliary Cancer
  • Blood & Lymphatic Cancer

MUSC Health Hematology Oncology

Address
1180 Hospital Drive
2nd Floor
Mount Pleasant, SC 29464
Hours
Specialties
  • Breast Cancer
  • Hematology/Oncology

MUSC Health Infusion Services at Nexton Medical Park

Address
MUSC Health Nexton Medical Park
5500 Front Street
Nexton Medical Park, Suite 140
Summerville, SC 29486
Hours
Specialties
  • Benign Hematology
  • Blood & Lymphatic Cancer

Common questions about genitourinary cancer

Your doctor can answer questions specific to your care, but we have compiled a list of some of the most common questions for your reference below.

Genitourinary cancers develop in the urinary system or male reproductive system. They include cancers of the prostate, kidney and bladder, as well as less common cancers of the testicles, penis, ureters and urethra. These cancers can behave very differently, so diagnosis and treatment depend on the specific type of cancer, where it is located and whether it has spread.

Yes. Genitourinary cancers can affect both women and men. Some cancers that develop in the urinary system, including the kidneys and bladder, can be diagnosed in anyone. Other genitourinary cancers are specific to men, such as prostate, penile and testicular cancers.

Genitourinary cancer care often involves several types of specialists. Urologists and urologic oncologists perform surgery and other procedures involving the urinary and male reproductive systems. Medical oncologists use medicines such as chemotherapy, immunotherapy and targeted therapy to treat cancer, while radiation oncologists specialize in treating cancer with radiation.

At Hollings, these specialists work together to develop a treatment plan based on your specific cancer and needs.

Symptoms depend on the type of cancer. Possible signs include blood in the urine, changes in urination, pain in the side or lower back, or a lump or swelling. Prostate cancer may cause urinary symptoms, although early prostate cancer often causes no symptoms at all.

Many of these symptoms can also be caused by conditions that are not cancer. Talk with your doctor if you notice new, persistent or concerning changes.

Treatment depends on the type and stage of cancer as well as your overall health and preferences. Some slow-growing cancers or small tumors may only need close monitoring. Other cancers may be treated with surgery, radiation, tumor ablation, chemotherapy, immunotherapy, targeted therapy or a combination of treatments.

Your care team will explain your options and work with you to develop a treatment plan that considers both treating the cancer and maintaining your quality of life.

Latest genitourinary cancer news