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High-Risk Breast Cancer

The MUSC Hollings Cancer Center High-Risk Breast Evaluation Program provides advanced screening, detection and treatment of breast cancer to women at high risk for developing the disease.

Am I at Increased Risk for Developing Breast Cancer?

Unsure if you are at high risk? This program is especially for women who have:

  • a strong family history of breast or ovarian cancer;
  • a history of abnormal cells in breast biopsies (atypical ductal hyperplasia [ADH] or lobular carcinoma in situ [LCIS]);
  • a personal history of breast cancer gene mutation known to be associated with breast cancer;
  • hormone-related characteristics, such as age of first period, first pregnancy, and menopause onset.

You may be referred to the program by your primary care provider or gynecologist based on that doctor’s assessment of your risk or based on a risk assessment provided on your mammogram report. You can also ask to be seen yourself. Every Hollings mammogram report provides a preliminary lifetime breast cancer risk assessment.

Once you have been taken under the care of the high-risk program, you will get regular follow-ups so that, if breast cancer develops, it should be caught early.

Early Detection & Risk Reduction

There are a number of things you can do to reduce your risk of breast cancer or to improve your chances of detecting a cancer earlier, which could make it easier to treat. Some of these options come with side effects, so you will decide with your doctor which actions are right for you. Those could include:

  • Chemoprevention: Chemotherapy pills to prevent cancer before it starts.
  • Prophylactic surgery: A mastectomy to remove your breasts before cancer can begin.
  • MRI screening: Advanced screening for detecting potential tumors.
  • Lifestyle modification: Reducing your alcohol intake, maintaining a healthy weight and ensuring you’re getting 150 minutes of moderate intensity exercise every week can help to reduce your risk.

Genetic Counseling

For patients with a family history of cancer, genetic testing can help determine how best to reduce risk. Genetic counseling at MUSC Hollings Cancer Center provides you with a quantitative breast cancer and genetic risk assessment, consultation on the pros and cons of genetic testing as well as the coordination of genetic testing and interpretation of test results. Patients who test positive are then followed in the Hollings Hereditary Cancer Clinic.

Hollings Hereditary Cancer Clinic

For people with a cancer risk gene, this clinic can help organize your follow-up care and minimize your risk. Genetic mutations that may be passed down through families can put you at higher risk for breast cancer. Some of these mutations can cause different types of cancer. For example, a mutation in the CHEK2 gene can increase the risk of colorectal cancer and breast cancer.

The Hollings Hereditary Cancer Clinic can help you to understand your genetic risk of cancer and steps that you can take to prevent cancer or find it earlier.

National Recognition in Cancer Care

MUSC Health has been recognized as High Performing in Cancer care in the 2025–2026 U.S. News & World Report rankings. This honor underscores our advanced expertise and dedication to providing patients with innovative treatments and personalized care.

The Hollings difference

High-Risk Breast Cancer Providers

Accepting New Patients
William Charles

William Charles, MD

Specialties
  • Pancreatic Cancer
  • Brain & Spine Cancer
Locations (1)
  • Lancaster, SC
Accepting New Patients
Amy Murrell

Amy Murrell, MD, FACS

4.9/5.0 - 528 rating
Specialties
  • General Surgery
  • Breast Cancer
Locations (4)
  • Cades, SC
  • Darlington, SC
  • Florence, SC
  • Mullins, SC
Accepting New Patients
Natalie Prince

Natalie Prince, FNP

Specialties
  • Breast Cancer
Locations (1)
  • FLORENCE, SOUTH CAROLINA
Reem Akel

Reem Akel, MD

4.8/5.0 - 162 rating
Specialties
  • Gynecologic Cancer
  • Blood & Lymphatic Cancer
Locations (1)
  • Florence, SC
Accepting New Patients
Sushma Pavuluri

Sushma Pavuluri, D.O.

Specialties
  • Hematology/Oncology
  • Blood & Lymphatic Cancer
Locations (1)
  • Florence, SC
Accepting New Patients
Wael Ghalayini

Wael Ghalayini, MD

4.8/5.0 - 374 rating
Specialties
  • Gynecologic Cancer
  • Blood & Lymphatic Cancer
Locations (1)
  • Florence, SC

High-Risk Care Locations

MUSC Hollings Cancer Network - Florence High-Risk Breast Program

Address
1590 Freedom Boulevard
Florence Womens Pavilion, Suite A
Florence, SC 29505
Hours
Specialties
  • Breast Cancer
  • Breast Surgery

MUSC Health Nexton Medical Center

Address
Nexton Medical Center
1850 Nexton Parkway
Summerville, SC 29486
Specialties
  • Biliary Cancer
  • Blood & Lymphatic Cancer

MUSC Health Hematology Oncology at East Cooper Medical Pavilion

Address
1600 Midtown Ave
3rd Floor
Mount Pleasant, SC 29464
Hours
Specialties
  • Breast Cancer
  • Hematology/Oncology

MUSC Hollings Cancer Center

Address
86 Jonathan Lucas St
Charleston, SC 29425
Hours
Specialties
  • Biliary Cancer
  • Blood & Lymphatic Cancer

MUSC Hollings Cancer Center Breast Care

Address
Beaufort Memorial Okatie Medical Pavilion
122 Okatie Center Boulevard North
Beaufort Memorial Okatie Medical Pavilion, Suite 110
Okatie, SC 29909
Specialties
  • Breast Cancer
  • Breast Surgery

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