Biorepository & Tissue Analysis Shared Resource

microscopic cells on a slide

The Biorepository & Tissue Analysis (BTA) Shared Resource provides investigators with access to meticulously collected and annotated human specimens as well as advanced human and animal tissue analyses that require state-of-the-art instrumentation and expertise. The shared resource comprises several integrated components including biospecimen and data repository, customized and readily available tissue microarrays (TMAs), and research pathology services such as histologic analysis of fixed, frozen, and stained tissues and analysis of experimental results.


Angela Yoon headshot


Angela J. Yoon, D.D.S.
Department of Stomatology, College of Dental Medicine & Department of Otolaryngology - Head and Neck Surgery, College of Medicine

Yuan Shao headshot

Research Pathologist

Yuan Shao, M.D., Ph.D. | 843-876-2345

Laboratory Technologist

Melriska Brown | 843-876-2345
Basic Science Building 739B


  1. Populate a central biospecimen and data repository.
    • Collect, process, and store human tissues according to established standard operating procedures (SOPs) with quality control verified by experienced pathologists at the time of accession.
    • Collect, process, and store saliva, urine, plasma, buffy coat, and other protocol-specific human biospecimens at the time of surgery/procedure according to established SOPs.
    • Link clinicopathologic data for each human specimen for research use.
    • Provide custom human TMAs in a cost-effective manner.
  2. Provide, develop, and modify tissue analysis services to support cancer research (human and animal).
    • Routine and custom staining procedures
    • DNA/RNA/protein isolation


The Biorepository & Tissue Analysis Shared Resource offers a wide range of services for investigators.

IRB Applications

A guide has been developed to assist investigators in determining what Internal Review Board (IRB) category is appropriate for their research. Please review prior to submitting your application.

IRB Submission Process

Equipment & Instrumentation

The Biorepository & Tissue Analysis Shared Resource is equipped with the technology to assist investigators in tissue analysis, biospecimen and data repository and tissue microarrays, and the expertise to perform these services.

Publication Acknowledgement

If you publish a manuscript including research supported by the Biorepository & Tissue Analysis Shared Resource, the Hollings Cancer Center recommends the following text to be placed in the acknowledgement section: "Supported in part by the Biorepository & Tissue Analysis Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313)."