Featured Trials

As an NCI-designated cancer center, MUSC Hollings Cancer Center offers clinical trials and therapies not available elsewhere in the state. Below are some of the newest and most promising clinical trials that are currently open to patients. 


two men in white lab coats pose in a lab

Hollings researchers are conducting a phase 1 clinical trial that is testing combinations of drugs typically used to treat other diseases like HIV and diabetes to see if they can effectively kill cancer cells while also being less toxic than some chemotherapy drugs. Called the Combination of Autophagy Selective Therapeutics (COAST) trial, this study is currently open to patients with an advanced solid tumor of any type.

HPV-Related Head and Neck Cancer Trial

Dr. John Kaczmar (left) and Russell Breault (right) inside a Hollings examination room. Photo by Josh Birch

The human papillomavirus (HPV) is a growing cause of head and neck cancer. Hollings is offering a nationwide phase two clinical trial that is testing the effectiveness of immunotherapy combined with a HPV cancer vaccine for patients with recurrent or metastatic HPV-associated head and neck cancer.

Multiple Myeloma Trial

Glenn Bachman (right) credits his wife (left) for helping him throughout his cancer journey. Photo by Josh Birch

After a transplant, the standard of care for multiple myeloma patients like Glenn Bachmann is to remain on maintenance chemotherapy for the rest of their lives. A Hollings phase III trial is evaluating whether the addition of a drug called daratumumab might allow patients who are in deep remission to stop after about two years of treatment.

Cervical Cancer Trial

January is National Cervical Cancer Awareness Month. Adobe Stock image

Hollings is enrolling patients in an ongoing trial that seeks to answer the question of whether adding immunotherapy to radiation treatment improves outcomes for patients with advanced cervical cancer. This trial represents some of the breakthroughs made in cervical cancer in recent years. Hollings will soon open enrollment for other cervical cancer trials.

TMIST Breast Cancer Trial

Dag Pavic with breast imaging device

Hollings is enrolling patients in a national clinical trial aimed at improving breast cancer screenings and treatment options for women with, and without, health insurance. The trial, called Tomosynthesis Mammographic Imaging Screening Trial (TMIST), will provide insights into which type of screening is best and how to improve future breast cancer care.

Lung-MAP Trial

Dr. John Wrangle

A bench-to-bedside-pioneered lung cancer immunology developed at Hollings is included in the national Lung-MAP clinical trial, which is currently enrolling patients at Hollings. The combination immunotherapy developed at Hollings will be offered as a treatment in the unmatched arm, which comprises patients with tumors that do not have mutations targetable with a drug, as opposed to a treatment arm.

COMPPARE Prostate Cancer Trial

Dr David Marshall looks at a computer screen in an operating room

Hollings is enrolling patients in a national clinical trial to help to determine the best, most cost-effective approach for treating prostate cancer through radiation therapy. Known as the COMPPARE study, the trial will compare the quality of life, side effects and cure rates for prostate cancer patients who are treated with either photon therapy or proton therapy.

Clinical Trials Search

Our patients have access to over 200 clinical trials that target virtually every type of cancer.