Translational Science Lab

gloved hand reaches out toward a transparent touch screen showing a brain and dna strand

The mission of the Translational Science Laboratory (TSL) is to facilitate the translation of basic science research to the clinical setting and vice versa with the intention of improving diagnosis and treatment strategies for cancer patients. The primary goals of the TSL are to:

  • Develop and validate a portfolio of novel biomarker assays that are available for translational studies.
  • Provide education to faculty and staff regarding novel technologies.
  • Provide project management for studies that utilize resources available through other shared resources, investigator laboratories, and outside vendors.
  • Initiate collaborations and form strategic partnerships between Hollings clinical investigators and pharmaceutical corporations.

The TSL works closely with clinical and translational scientists to drive the development and utilization of novel biomarker assays to provide the most innovative pre-clinical and correlative science studies associated with early phase oncology clinical trials.

Staff

Jian Ouyang headshot 

Director

Jian Ouyang, Ph.D.
ouyangj@musc.edu

Mrinmoyee Majumder headshot 

Director of Operations

Mrinmoyee Majumder, Ph.D.
majumder@musc.edu

Na Qu Headshot 

Research Specialist III

Na Qu, Ph.D.
qu@musc.edu

Shuang Li headshot 

Research Specialist III

Shuang Li, Ph.D.
shl229@musc.edu

Services and Expertise

  • Automated Purification of DNA, RNA, miRNA from cells, blood, FFPE, or fresh frozen tissue samples.
  • Custom targeted cancer NGS library generation.Single-Cell Sequencing (10X Genomics).
  • Droplet digital PCR (BioRad QX200).
  • The RNAi Consortium’s (TRC) genome-wide lentivirus-based mouse and human shRNA libraries.
  • Data analysis. The TSL works closely with the Bioinformatics Core (Dr. Stefano Berto) to help researchers to analyze sequencing data.

Consultation

Projects that involve TSL services — especially scRNAseq, snRNAseq, Bulk RNAseq and ddPCR — begin with a free initial consultation to discuss experimental design, feasibility and timeline. Please consult Dr. Majumder (majumder@musc.edu) or Dr. Ouyang (ouyangj@musc.edu) at least 4 weeks prior to the intended sample submission.

To request this service, log in to Infinity and select TSL Consult Request.

Letter of Support

Dr. Ouyang can provide a letter of support (LOS) prior to submitting a grant proposal. You must make the request at least 5 business days prior to the submission deadline.

To request this service, log in to Infinity and select TSL Letter of Support.

Publication Acknowledgement

If you publish a manuscript including research supported by the Translational Science Lab Shared Resource, the following text is to be placed in the acknowledgement section: "Supported in part by the Translational Science Lab Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313)."