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Translational Science Lab

The mission of the Translational Science Laboratory (TSL) is to facilitate the translation of basic science research to the clinical setting and vice versa with the intention of improving diagnosis and treatment strategies for cancer patients. The primary goals of the TSL are to:

  • Develop and validate a portfolio of novel biomarker assays that are available for translational studies.
  • Provide education to faculty and staff regarding novel technologies.
  • Provide project management for studies that utilize resources available through other shared resources, investigator laboratories, and outside vendors.
  • Initiate collaborations and form strategic partnerships between MUSC Hollings Cancer Center clinical investigators and pharmaceutical corporations.

The TSL works closely with clinical and translational scientists to drive the development and utilization of novel biomarker assays to provide the most innovative pre-clinical and correlative science studies associated with early phase oncology clinical trials.

Staff

Jian Ouyang, Ph.D.

Director, Translational Science Lab, Hollings Cancer Center Assistant Professor, Department of Biochemistry and Molecular Biology
mail ouyangj@musc.edu View Faculty Profile open_in_new View Research Profile open_in_new

As an enthusiastic biochemist and a hand-on problem solver, my research has been focusing on the regulation of DNA damage repair and gene expression by post-translational modifications (PTMs). I have shown that PTM by small ubiquitin-like modifier (SUMO) can recruit epigenetic modifiers to regulate chromatin structure, and can recruit DNA repair factors in response to damaged DNA. Alterations in both transcription and DNA repair system are sources of genomic instability, although the underlying molecular mechanisms are quite different.

My recent work investigates the role of RNA, a product of transcription, in repairing damaged DNA. My ultimate research goal is to identify potential therapeutic targets based on mechanistic insights into the maintenance of genomic integrity, and develop potential targeted therapies for cancer.

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Mrinmoyee Majumder, Ph.D.

Assistant Director, Translational Science Lab Shared Resource, MUSC Hollings Cancer Center Assistant Director, Shared Resources Education & Training, MUSC Hollings Cancer Center
mail majumder@musc.edu Translational Science Lab arrow_forward

Mrinmoyee Majumder, Ph.D., provides strategic, operational, and scientific leadership for the Translational Science Lab Shared Resource (TSL), overseeing day-to-day operations while driving service integration, quality, and growth to support translational and clinical research. She partners closely with investigators to design and execute high-impact correlative studies, ensures compliance with institutional and NCI standards, and collaborates with external vendors and industry partners to advance scientific capabilities and expand service offerings. Through these efforts, she leads the continuous evolution of TSL to meet the changing needs of Hollings Cancer Center members and MUSC.

In her role as Assistant Director of Shared Resources Education & Training, Dr. Majumder collaborates with institutional leadership to develop and implement coordinated training initiatives that enhance awareness and utilization of shared resources. She plays a key role in strengthening engagement across the research community, fostering connections among trainees, faculty, and staff to support a collaborative and well-integrated research environment.

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Multiomics Specialists

Youtao Liu, Ph.D.
liuyo@musc.edu

Pooja Pradeep, Ph.D.
pradeep@musc.edu

Services and Expertise

  • Automated Purification of DNA, RNA, miRNA from cells, blood, FFPE, or fresh frozen tissue samples.
  • Custom targeted cancer NGS library generation. Single-Cell Sequencing (10X Genomics).
  • Droplet digital PCR (BioRad QX200).
  • The RNAi Consortium’s (TRC) genome-wide lentivirus-based mouse and human shRNA libraries.
  • Data analysis. The TSL works closely with the Bioinformatics Core (Dr. Stefano Berto) to help researchers to analyze sequencing data.
  • Access to genome-wide human & mouse libraries that encode a total of almost 160,000 shRNA clones against over 41,000 genes.

Consultation

Projects that involve TSL services — especially scRNAseq, snRNAseq, Bulk RNAseq and ddPCR — begin with a free initial consultation to discuss experimental design, feasibility and timeline. Please consult Dr. Majumder (majumder@musc.edu) or Dr. Ouyang (ouyangj@musc.edu) at least four weeks prior to the intended sample submission.

To request this service, log in to Infinity and select TSL Consult Request.

Letter of Support

Dr. Ouyang can provide a letter of support (LOS) prior to submitting a grant proposal. You must make the request at least five business days prior to the submission deadline.

To request this service, log in to Infinity and select TSL Letter of Support.

Publication Acknowledgment

If you publish a manuscript including research supported by the Translational Science Lab Shared Resource, the following text is to be placed in the acknowledgement section: "Supported in part by the Translational Science Lab Shared Resource, Hollings Cancer Center, Medical University of South Carolina (P30 CA138313)."