Dr. Lee Leddy in clinic at Hollings Cancer Center
Dr. Lee Leddy in clinic at Hollings Cancer Center

MUSC Hollings Cancer Center is one of a small number of health care centers in the U.S. offering focused sarcoma care. Our team includes fellowship-trained clinicians in orthopaediconcology, surgical oncology and medical oncology, all with a clinical focus on sarcoma patients. There are only about 15,000 new cases of sarcoma diagnosed across the country each year. Since this cancer is so rare, it is important that you’re treated at a center with a team of doctors experienced in this disease. Our program also has experienced pathology and musculoskeletal radiology experts for proper diagnosis, which is crucial for effective treatment.

Diagnosis & Treatment of Sarcoma

Advanced Imaging

MRI, PET and CT scans allow for accurate interpretation, which aids surgical planning and radiation planning.

Surgical Treatment

Our surgeons are not only experienced in the removal of sarcomas, but also in how best to reconstruct the tissue or skeletal defect, maximizing the patient’s post-operative function. Procedures include biopsy of primary tumors, removal of primary tumors, limb-sparing surgery and surgical treatment of metastatic disease.

Systemic Therapies

Our experts guide the selection of appropriate post-surgical therapy and manage systemic therapy options specific to your sarcoma subtype including bone, soft tissue sarcomas and non-gastrointestinal stromal tumors.


Our pathologists take advantage of advancements in cancer genetics and technology using genetic markers to aid in diagnosis and prognosis.

Medical Management

Personalized tumor staging, chemotherapy and radiation plans are developed by a multidisciplinary team experienced in sarcoma.

Clinical Trials

Clinical trials for cutting-edge sarcoma therapies are showing promising results for patients and helping to further our understanding of this disease. Dedicated sarcoma trials are available including trials specific for leiomyosarcoma, liposarcoma, GIST, angiosarcoma and bone tumors such as chondrosarcoma.

Types of Sarcoma We Treat

Bone Sarcoma:

  • Osteosarcoma
  • Ewing’s sarcoma
  • Chondrosarcoma
  • Pleomorphic undifferentiated sarcoma of the bone

Soft Tissue Sarcoma

  • Pleomorphic undifferentiated sarcoma
  • Synovial sarcoma
  • Liposarcoma
  • Fibrosarcoma
  • Myxofibrosarcoma
  • Dermatofibrosarcoma protuberans (DFSP)
  • Leiomyosarcoma
  • Angiosarcoma
  • Lymph angiosarcoma
  • Epithelioid sarcoma
  • Desmoid
  • Atypical lipomatous tumor
  • Gastrointestinal stromal tumor (GIST)
  • Rhabdomyosarcoma
  • Clear cell sarcoma
  • Myxoid sarcoma
  • Alveolar sarcoma
  • Solitary Fibrous tumor