Research News at Hollings

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Hollings researchers challenge necessity of lymphodepleting chemotherapy prior to CAR-T-cell treatment

two CAR-T cell researchers pose in a lab at MUSC Hollings Cancer Center

Hollings researcher Richard O’Neil, Ph.D., and graduate student Megan Tennant, in a paper published in Molecular Therapy, showed that encoding CAR-T-cells with instructions to create a hyperactive form of protein STAT5 prompted the CAR-T-cells to engraft without requiring lymphodepletion.

The paper shows evidence that the engraftment process is cell autonomous.

Read about the research

 

Dr Hamza Hashmi chats with a nurse

Outpatient Stem Cell

MUSC Hollings Cancer Center researchers find that autologous stem cell transplant for multiple myeloma is usually safe as outpatient procedure.
image of two tobacco researchers in hallway

Quitting for Good

If a first try at quitting smoking doesn't work, should the same method be tried again? Or a new method? Hollings researchers are seeking answers.

a scientist sits at his desk surrounded by notes

Breast Cancer Drug Development

A Hollings researcher's startup got a Small Business Technology Transfer grant to develop triple negative breast cancer findings into a potential drug.

Dr. Anand Mehta (left) and Shaaron Ochoa-Rios (right)

Cancer Biomarker

MUSC team finds a new, more specific biomarker for a liver cancer type. Currently, no specific diagnostic tools of this type exist for this disease.

woman standing in a hallway smiling with sign on the wall that says Cancer Control

Evidence for Remote Trials

Will remote trials overcome the barriers that make it difficult for underserved populations to participate in clinical trials? A Hollings researcher weighs in.

a doctor speaks with a patient in an exam room

Preventing Cancer's Return

An MUSC Hollings Cancer Center doctor is leading a national trial to test whether drugs used after large B-cell lymphoma returns could instead prevent relapse.

a woman in lab coat and gloves sits at a console

Risk Biomarkers

A Hollings researcher wants to ID risk biomarkers to enable doctors to stop a serious side effect of stem cell transplant before it happens.

a woman stands at a podium

Sneaky Centrosomes

An MUSC Hollings Cancer Center team ID'd a protein that helps cancer cells to navigate the cell division process despite an abnormality that should doom them.
a man speaks at a podium with large screens on the wall behind him

Doll-Wynder Award

Dr. Michael Cummings was honored for the groundbreaking advances he's made over a 40-year career in tobacco control research.