Research News at Hollings

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Hollings researchers challenge necessity of lymphodepleting chemotherapy prior to CAR-T-cell treatment

two CAR-T cell researchers pose in a lab at MUSC Hollings Cancer Center

Hollings researcher Richard O’Neil, Ph.D., and graduate student Megan Tennant, in a paper published in Molecular Therapy, showed that encoding CAR-T-cells with instructions to create a hyperactive form of protein STAT5 prompted the CAR-T-cells to engraft without requiring lymphodepletion.

The paper shows evidence that the engraftment process is cell autonomous.

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